Perceived weight status and risk of weight gain across life in US and UK adults

Background: Correctly identifying oneself as being overweight is presumed to be a prerequisite to successful weight management. The present research examined the effect that perceiving oneself as being ‘overweight’ has on risk of future weight gain in US and UK adults. Methods: Data from three longitudinal studies; US National Longitudinal Study of Adolescent Health (Add Health) 2001/2002–2008/2009, UK National Child Development Study (NCDS) 1981–2002/2004, and Midlife in the United States (MIDUS) 1995/1996–2004/2005, were used to examine the impact of perceiving oneself as being overweight on weight gain across adulthood in over 14 000 US and UK adults. Results: Participants who perceived their weight status as being overweight were at an increased risk of subsequent weight gain. This effect was observed irrespective of weight status at baseline and whether weight status perceptions were accurate or inaccurate. In the MIDUS sample, perceiving oneself as being overweight was associated with overeating in response to stress and this mediated the relationship between perceived overweight and weight gain. Conclusions: Perceiving oneself as being ‘overweight’ is counter-intuitively associated with an increased risk of future weight gain among US and UK adults

Darwinizing the philosophy of music education.

Thesis (Ph.D.)-University of KwaZulu-Natal, Durban, 2011.Educational philosophy generally and the Philosophy of Music Education in particular have been slow to consider in any real depth the findings of those sciences most concerned with explaining human nature, that is, the attributes (capacities, aptitudes, predilections, appetites) we have in common because we share the same genome, much of which we also share with other species. There are several such sciences which may collectively be called Darwinian Science in that they all take as axiomatic Darwin‘s explanation for how life evolves according to the law of natural selection – a simple, mindless and purposeless algorithm that has played out for over four billion years and which continues to do so, driving not only biological evolution but, as this study argues, cultural evolution as well. Evolutionary Psychology (including Biomusicology and Evolutionary Aesthetics), Cognitive Neuroscience and Gene- Culture Coevolution Theory are the overlapping fields that this study draws from in developing an understanding of the adapted mind useful for engaging with questions germane to the Philosophy of Music Education, principally those concerning the nature and value of music and how best it should feature in general education. These are questions that have not hitherto been addressed from a Darwinian perspective. This study develops such a perspective and applies it not only to questions around music‘s educational values and possibilities, but to more encompassing philosophical questions, wherein the goals of music education are made accountable in relation both to Dewey‘s ideal of society as a function of education, and to an ecozoic vision of a sustainable planetary habitat of interdependent and interconnected life forms

Reliance: Herreshoff Marine Museum

The Roger Williams University Reliance team is working in cooperation with the Herreshoff Marine Museum in Bristol, RI to create a 1/6th scale model of the 1901 Americas Cup defender, the Reliance. The project can be broken up into two sub-projects. The first, to design a museum-quality cradle to hold the 24ft fully rigged model at a 15O angle. The second sub-project is to perform full strength/structural analysis of all the critical components on the model to ensure that their strength is great enough to withstand the applied forces. This second sub-project is going to be the focus of the spring 2013 semester while the Fall 2012 semester focused on the cradle design. After determining our final cradle design, structural analysis validated the use of two square channel 4”x4”x0.5” steel columns for the ‘legs’ of the cradle, while 3/8” bolts secured C 3x3.5 A36 steel outrigger beams to the center beam constructed of American Standard S 3x5.7 A36 steel

Changes in Sensitivity of Reward and Motor Behavior to Dopaminergic, Glutamatergic, and Cholinergic Drugs in a Mouse Model of Fragile X Syndrome

Fragile X syndrome (FXS) is a leading cause of intellectual disability. FXS is caused by loss of function of the FMR1 gene, and mice in which Fmr1 has been inactivated have been used extensively as a preclinical model for FXS. We investigated the behavioral pharmacology of drugs acting through dopaminergic, glutamatergic, and cholinergic systems in fragile X (Fmr1-/Y) mice with intracranial self-stimulation (ICSS) and locomotor activity measurements. We also measured brain expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine biosynthesis. Fmr1-/Y mice were more sensitive than wild type mice to the rewarding effects of cocaine, but less sensitive to its locomotor stimulating effects. Anhedonic but not motor depressant effects of the atypical neuroleptic, aripiprazole, were reduced in Fmr1-/Y mice. The mGluR5-selective antagonist, 6-methyl-2-(phenylethynyl)pyridine (MPEP), was more rewarding and the preferential M1 antagonist, trihexyphenidyl, was less rewarding in Fmr1-/Y than wild type mice. Motor stimulation by MPEP was unchanged, but stimulation by trihexyphenidyl was markedly increased, in Fmr1-/Y mice. Numbers of midbrain TH+ neurons in the ventral tegmental area were unchanged, but were lower in the substantia nigra of Fmr1-/Y mice, although no changes in TH levels were found in their forebrain targets. The data are discussed in the context of known changes in the synaptic physiology and pharmacology of limbic motor systems in the Fmr1-/Y mouse model. Preclinical findings suggest that drugs acting through multiple neurotransmitter systems may be necessary to fully address abnormal behaviors in individuals with FXS

Establishing a core outcome set for peritoneal dialysis : report of the SONG-PD (standardized outcomes in nephrology-peritoneal dialysis) consensus workshop

Outcomes reported in randomized controlled trials in peritoneal dialysis (PD) are diverse, are measured inconsistently, and may not be important to patients, families, and clinicians. The Standardized Outcomes in Nephrology-Peritoneal Dialysis (SONG-PD) initiative aims to establish a core outcome set for trials in PD based on the shared priorities of all stakeholders. We convened an international SONG-PD stakeholder consensus workshop in May 2018 in Vancouver, Canada. Nineteen patients/caregivers and 51 health professionals attended. Participants discussed core outcome domains and implementation in trials in PD. Four themes relating to the formation of core outcome domains were identified: life participation as a main goal of PD, impact of fatigue, empowerment for preparation and planning, and separation of contributing factors from core factors. Considerations for implementation were identified: standardizing patient-reported outcomes, requiring a validated and feasible measure, simplicity of binary outcomes, responsiveness to interventions, and using positive terminology. All stakeholders supported inclusion of PD-related infection, cardiovascular disease, mortality, technique survival, and life participation as the core outcome domains for PD

Bodyweight Perceptions among Texas Women: The Effects of Religion, Race/Ethnicity, and Citizenship Status

Despite previous work exploring linkages between religious participation and health, little research has looked at the role of religion in affecting bodyweight perceptions. Using the theoretical model developed by Levin et al. (Sociol Q 36(1):157–173, 1995) on the multidimensionality of religious participation, we develop several hypotheses and test them by using data from the 2004 Survey of Texas Adults. We estimate multinomial logistic regression models to determine the relative risk of women perceiving themselves as overweight. Results indicate that religious attendance lowers risk of women perceiving themselves as very overweight. Citizenship status was an important factor for Latinas, with noncitizens being less likely to see themselves as overweight. We also test interaction effects between religion and race. Religious attendance and prayer have a moderating effect among Latina non-citizens so that among these women, attendance and prayer intensify perceptions of feeling less overweight when compared to their white counterparts. Among African American women, the effect of increased church attendance leads to perceptions of being overweight. Prayer is also a correlate of overweight perceptions but only among African American women. We close with a discussion that highlights key implications from our findings, note study limitations, and several promising avenues for future research

Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism

The OPRM1 A118G polymorphism is the most widely studied μ-opioid receptor (MOR) variant. Although its involvement in acute alcohol effects is well characterized, less is known about the extent to which it alters responses to opioids. Prior work has shown that both electrophysiological and analgesic responses to morphine but not to fentanyl are moderated by OPRM1 A118G variation, but the mechanism behind this dissociation is not known. Here we found that humanized mice carrying the 118GG allele (h/mOPRM1-118GG) were less sensitive than h/mOPRM1-118AA littermates to the rewarding effects of morphine and hydrocodone but not those of other opioids measured with intracranial self-stimulation. Reduced morphine reward in 118GG mice was associated with decreased dopamine release in the nucleus accumbens and reduced effects on GABA release in the ventral tegmental area that were not due to changes in drug potency or efficacy in vitro or receptor-binding affinity. Fewer MOR-binding sites were observed in h/mOPRM1-118GG mice, and pharmacological reduction of MOR availability unmasked genotypic differences in fentanyl sensitivity. These findings suggest that the OPRM1 A118G polymorphism decreases sensitivity to low-potency agonists by decreasing receptor reserve without significantly altering receptor function

Demonstration of a timescale based on a stable optical carrier

We report on the first timescale based entirely on optical technology. Existing timescales, including those incorporating optical frequency standards, rely exclusively on microwave local oscillators owing to the lack of an optical oscillator with the required frequency predictability and stability for reliable steering. We combine a cryogenic silicon cavity exhibiting improved long-term stability and an accurate 87 Sr lattice clock to form a timescale that outperforms them all. Our timescale accumulates an estimated time error of only 48 ± 94     ps over 34 days of operation. Our analysis indicates that this timescale is capable of reaching a stability below 1 × 10 − 17 after a few months of averaging, making timekeeping at the 10 − 18 level a realistic prospect